Most Christians in the Western World have not experienced the kind of persecution to which Paul is referring. Probably the worst persecution that we receive is losing (temporarily, hopefully) the friendship of someone close to us because of our belief in the death and Resurrection of Jesus Christ. Here, Paul is talking about those early Christians who gave their lives for the Gospel. I would guess that most of us have wondered, at some time or other, how far we would go for the Gospel. Would I really lay down my life for Jesus? Paul tells us that we should consider our physical bodies as dead already.
Since this is true, we should consider our physical bodies already dead. But our Spirit will always be alive because of what Jesus did for us at Calvary. So, if we are attempting to live the lifestyle that Jesus wants us to, isn’t the decision already made? We agreed to die with Christ and mortify (put to death) our fleshly desires so that we will be raised with Christ in our new immortal bodies. It is all about faith and trust. Will God do what He said or not? The answer is “Yes, of course, He will.” In His mercy, He will protect and perfect us and in His justice, He will repay the persecutors
“The Gospel has come to you because it’s on its way to someone else.” -Anonymous